Valdez V, Ma M, Gouveia B, Zhang R#, Petry S#. HURP facilitates spindle assembly by stabilizing microtubules and working synergistically with TPX2. Nat Commun (2024) 15, 9689.
Garg A, Jansen S, Greenberg L, Zhang R, Lavine KJ, Greenberg MJ. Dilated cardiomyopathy-associated skeletal muscle actin (ACTA1) mutation R256H disrupts actin structure and function and causes cardiomyocyte hypocontractility. Proc Natl Acad Sci USA (2024) 121 (46) e2405020121.
Dai J*, Ma M*, Niu Q, Eisert RJ, Wang X, Das P, Lechtreck KF, Dutcher SK, Zhang R#, Brown A#. Mastigoneme structure reveals insights into the O-linked glycosylation code of native hydroxyproline-rich helices. Cell (2024) 187, 1907–21
Jamali K#, Käll L, Zhang R, Brown A, Kimanius D#, Scheres SHW#. Automated model building and protein identification in cryo-EM maps. Nature (2024) 628, 450–457
Leung MR*, Zeng J*, Wang X, Roelofs MC, Huang W, Chiozzi RZ, Hevler JF, Heck AJR, Dutcher SK, Brown A, Zhang R#, Zeev-Ben-Mordehai T#. Structural specializations of the sperm tail. Cell (2023) 186, 2880–2896
Travis SM*, Mahon BP*, Huang W, Ma M, Rale MJ, Kraus J, Taylor DJ, Zhang R#, Petry S#. Integrated model of the vertebrate augmin complex. Nat Commun (2023) 14, 2072.
Gui M, Wang X, Dutcher SK, Brown A#, Zhang R#. Ciliary central apparatus structure reveals mechanisms of microtubule patterning. Nat Struct Mol Biol (2022) 29, 483–492.
Hao L, Zhang R, Lohman TM. Heterogeneity in E. coli RecBCD Helicase-DNA Binding and Base Pair Melting. J Mol Biol (2022) 433 (18), 167147.
Song X, Yang F, Liu X, Xia P, Yin W, Wang Z, Wang Y, Yuan X, Dou Z, Jiang K, Ma M, Hu B, Zhang R, Xu C, Zhang Z, Ruan K, Tian R, Li L, Liu T, Hill DL, Zang J#, Liu X#, Li J#, Cheng J#, Yao X#. Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis. Nat Chem Biol (2021) 17, 1314–1323
Wang X*, Fu Y*, Beatty WL, Ma M, Brown A, Sibley LD#, Zhang R#. Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins. Nat Commun (2021) 12, 4076–81.
Gui M, Ma M, Sze-Tu E, Wang X, Koh F, Zhong ED, Berger B, Davis JH, Dutcher SK, Zhang R#, Brown A#. Structures of radial spokes and associated complexes important for ciliary motility. Nat Struct Mol Biol (2021) 28, 29–37.
Brown A, Zhang R. Primary Cilia: A Closer Look at the Antenna of Cells. Curr Biol (2020) 30, R1494–R1496.
Ma M, Stoyanova M, Rademacher G, Dutcher SK, Brown A#, Zhang R#. Structure of the decorated ciliary doublet microtubule. Cell (2019) 179, 909-12.
Song JG, King MR, Zhang R, Kadzik RS, Thawani A, Petry S. Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules. J Cell Biol (2018) 217 (7): 2417-2428
Eva Nogales Lab @ UCB
LaFrance BJ, Roostalu J, Henkin G, Greber BJ, Zhang R, Normanno D, McCollum CO, Surrey T#, Nogales E#. Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules. Proc Natl Acad Sci USA (2022) 119 (2), e2114994119.
Eshun-Wilson L, Zhang R, Portran D, Nachury MV, Toso DB, Löhr T, Vendruscolo M, Bonomi M, Fraser JS, Nogales E. Effects of α-tubulin acetylation on microtubule structure and stability. Proc Natl Acad Sci USA (2019) 116 (21): 10366-371
Zhang R#, LaFrance B, Nogales E#. Separating the effects of nucleotide and EB binding on microtubule structure. Proc Natl Acad Sci USA (2018) 115 (27): E6191-E6200
Howes SC*, Geyer EA*, LaFrance B, Zhang R, Kellogg EH, Westermann S, Rice LM, Nogales E. Structural and functional differences between porcine brain and budding yeast microtubules. Cell Cycle (2018) 17(3): 278-287
Zhang R*, Roostalu J*, Surrey T#, Nogales E#. Structural insight into TPX2-stimulated microtubule assembly. Elife (2017) 6: e30959
Howes SC, Geyer EA, LaFrance B, Zhang R, Kellogg EH, Westermann S, Rice LM, Nogales E. Structural differences between yeast and mammalian microtubules revealed by cryo-EM. J Cell Biol (2017) 216(9): 2669-2677
Liu T, Dai A, Cao Y, Zhang R, Dong MQ, Wang HW. Structural Insights of WHAMM’s Interaction with Microtubules by Cryo-EM. J Mol Biol (2017) 429 (9): 1352-1363
Nogales E, Zhang R. Visualizing Microtubule Structure and Interactions with Associated Proteins. Curr Opin Struct Biol (2016) 37: 90-96
Feng R, Sang Q, Kuang Y, Sun X, Yan Z, Zhang S, Shi J, Tian G, Luchniak A, Fukuda Y, Li B, Yu M, Chen J, Xu Y, Guo L, Qu R, Wang X, Sun Z, Liu M, Shi H, Wang H, Feng Y, Shao R, Chai R, Li Q, Xing Q, Zhang R, Nogales E, Jin L, He L, Gupta ML, Cowan NJ, Wang L. Mutations in TUBB8 and Human Oocyte Meiotic Arrest. N Engl J Med (2016) 374: 223-232
Zhang R#, Nogales E#. A New Protocol to Accurately Determine Microtubule Lattice Seam Location. J Struct Biol (2015) 192(2): 245-254
Shen QT*, Ren X*, Zhang R*, Lee IH, Hurley JH. HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons. Science (2015) 350(6259): aac5137
Zhang R, Alushin GM, Brown A, Nogales E. Mechanistic Origin of Microtubule Dynamic Instability and its Modulation by EB Proteins. Cell (2015) 162, 849-859
Alushin GM*, Lander GC*, Kellogg EH*, Zhang R, Baker D, Nogales E. High resolution microtubule structures reveal the structural transitions in α/β tubulin upon GTP hydrolysis. Cell (2014) 157(5): 1117-1129
Wah Chiu Lab @ BCM
Zhang R, Hryc CF, Cong Y, Liu X, Jakana J, Gorchakov R, Baker ML, Weaver SC, Chiu W. 4.4 Å cryo-EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus. EMBO J (2011) 30(18): 3854-3863
Zhang R, Hu X, Khant H, Ludtke SJ, Chiu W, Schmid MF, Frieden C, Lee JM. Interprotofilament interactions between Alzheimer’s Aβ1-42 peptides in amyloid fibrils revealed by cryoEM. Proc Natl Acad Sci USA (2009) 106: 4653-4658
Parmenter CD, Cane MC, Zhang R, Stoilova-McPhie S. Cryo-electron microscopy of coagulation Factor VIII bound to lipid nanotubes. Biochem Biophys Res Commun (2008) 366(2): 288-93