We primarily use high-resolution single particle cryo-EM to pursue the native structures of macromolecular complexes that are directly isolated from various organisms, ranging from green algae to mammals. Most of our current projects are related to microtubules and cilia.
Doublet Microtubules from Sea Urchin Sperm and Bovine Sperm
Cortical Microtubules from Human Parasite Toxoplasma Gondii
Central Apparatus within the Axoneme
Radial Spokes within the Axoneme
Ciliary Doublet Microtubule from Chlamydomonas